Table 2. The association of genotype and allele of GREM2 rs11588607/rs4454537 polymorphism with osteoporosis risk.

Genotype	Genotypes and alleles	Frequencies, N(%)		OR (95% CI)	P
		Cases (n=310)	Controls (n=339)
Rs11588607
	CC	145 (46.8%)	169 (49.9%)	1.0
	CT	133 (42.9%)	143 (42.2%)	1.08 (0.78,1.50)	0.626
	TT	32 (10.3%)	27 (8.0%)	1.38 (0.79,2.41)	0.257
	TT+CT	165 (53.2%)	170 (50.1%)	1.13 (0.83,1.54)	0.433
	CC+TT	278 (89.7%)	312 (92.0%)	1.0
	TT	32 (10.3%)	27 (8.0%)	1.33 (0.78,2.28)	0.298
	C allele	423 (68.2%)	481 (70.9%)	1.0
	T allele	197 (31.8%)	197 (29.1%)	1.14 (0.90,1.44)	0.288
Rs4454537
	TT	156 (50.3%)	192 (56.6%)	1.0
	TC	124 (40.0%)	127 (37.5%)	1.20 (0.87,1.66)	0.268
	CC	30 (9.7%)	20 (5.9%)	1.85 (1.01,3.38)	0.047
	CC+TC	154 (49.7%)	147 (43.4%)	1.29 (0.95,1.76)	0.107
	TC+TT	280 (90.3%)	319 (94.1%)	1.0
	CC	30 (9.7%)	20 (5.9%)	1.71 (0.95,3.08)	0.074
	T allele	436 (70.3%)	511 (75.4%)	1.0
	C allele	184 (29.7%)	167 (24.6%)	1.29 (1.01,1.65)	0.041

Bold values are statistically significant (P<0.05).