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. 2020 Mar 19;37:100980. doi: 10.1016/j.molmet.2020.100980

Figure 7.

Figure 7

Effect of pharmacologic blockade of GLP-1R on glucose control in FXR−/− (KO) and wild-type (WT) mice at postoperative weeks 4 and 14. RYGB and S-WM mice underwent OGTT. The glucose excursion curve after sterile saline with or without Ex-9 administered by intraperitoneal injection in fasted WT (A) and KO (B) mice at postoperative week 4. The glucose excursion curve after similar treatment in WT (C) and KO (D) mice at postoperative week 14. Glucose AUC 0–120min with saline or Ex-9 pretreatment in both WT and KO mice at postoperative weeks 4 (E) and 14 (F). ∗∗ = P < 0.01 S-WM vs. RYGB in WT mice by two-way ANOVA with Tukey's post hoc test. Data are shown as mean ± SEM. S-WM: sham-operated animals weight matched to RYGB-operated mice; RYGB: Roux-en-Y gastric bypass surgery; KO, knockout; WT, wild type. OGTT: oral glucose tolerance tests, AUC: area under curve.