Table 3.
Urine hrHPV detection by cervical cytology and histology.
| Groups compared | Age | Urine samples |
Cervical samples |
Prevalence % (95% CI) |
Sensitivity % (95% CI) |
Specificity % (95% CI) |
PPV % (95% CI) |
NPV % (95% CI) |
||
|---|---|---|---|---|---|---|---|---|---|---|
| ASC-H/HSIL | ASCUS/LSIL | |||||||||
| 1 | Urine hrHPV detection (for high grade cytology (ASC-H/HSIL) versus low grade cytology (ASCUS/LSIL)) | All (NS) | hrHPV positive | 5 | 18 | 22.6 (12.3–35.3) |
35.7 (14.0–34.4) |
62.5 (47.3–75.7) |
21.7 (8.3–44.2) |
76.9 (60.3–88.3) |
| hrHPV negative | 9 | 30 | ||||||||
| ≥ 30 ∗∗ | hrHPV positive | 5 | 13 | 23.4 (12.8–38.4) |
45.4 (18.1–75.4) |
63.9 (46.2–78.7) |
27.8 (10.7–53.6) |
79.3 (59.7–91.3) |
||
| hrHPV negative | 6 | 23 | ||||||||
| ≥ CIN 2 | ≤ CIN 1 | |||||||||
| 1,2 # | Urine hrHPV detection (for ≥ CIN 2 versus ≤ CIN 1) | All ∗ | hrHPV positive | 15 | 20 | 29.2 (21.2–38.6) |
45.5 (28.5–63.4) |
75.0 (63.8–83.7) |
42.8 (26.7–60.5) |
76.9 (65.8–85.4) |
| hrHPV negative | 18 | 60 | ||||||||
| ≥30 (NS) | hrHPV positive | 12 | 16 | 30.3 (21.2–41.1) |
44.4 (26.0–64.3) |
74.1 (61.2–84.1) |
42.8 (25.0–62.6) |
75.4 (62.4–85.1) |
||
| hrHPV negative | 15 | 46 | ||||||||
# (11 patients did not have colposcopies); hrHPV: high-risk human papillomavirus; PPV: Positive predictive value; NPV: Negative predictive value; CI: Confidence interval; (NS): Not Significant; CIN: Cervical intra intraepithelial neoplasia; ASC-H: Atypical squamous cells, cannot rule out HSIL; HSIL: High-grade squamous intraepithelial lesion; ASCUS: Atypical squamous cells of undetermined significance; LSIL: Low-grade squamous intraepithelial lesion.
∗∗p < 0.01.
∗p < 0.05.