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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Neurobiol Aging. 2019 Dec 16;89:41–54. doi: 10.1016/j.neurobiolaging.2019.12.009

Fig. 11.

Fig. 11.

Proposed mechanisms by which ROCK inhibitors reduce the amount of oligomeric tau. ROCK inhibitors inactivated tau kinases, including GSK3β, via AKT activation. ROCK inhibitors also inactivated caspase, and decreased the C-terminal truncation of tau and formation of tau oligomers, which are 2 forms of tau linked to toxicity. ROCK inhibitors also upregulated autophagy and proteasome and reduced total tau levels. Abbreviations: GSK3β, glycogen synthase kinase 3β; ROCK, Rho-associated coiled-coil protein kinase.