Fig. 1.

miR-324-3p has been shown to be increased in ectopic pregnancy compared with tissues obtained from voluntary termination of pregnancy. This miRNA has a repressive interaction with 3′-UTR of KISS1 [26]. Kisspeptins have essential roles in implantation through regulation of leukemia inhibitory factor (LIF) [27]. LIF participates to embryo attachment and decidualization. It also regulates expression of MMP and VEGF thus contributing in trophoblast invasion and angiogenesis [28]. Consequently, aberrant expression of miR-324-3p can alter all of these steps.