Table 2.

Key features of the search protocol used to find the final population kinetic model

Optimization routine	Added covariate	Target parameter	LL	-2(LL)	AIC
Naive			−72	152	165
FOCE LB			57	−113	−93
+  2 elimination routes			67	−134	−110
	Time ≤ 20 min	k12	111	−219	−193
	Time ≤ 20 min	kb	113	−227	−200
	Time ≤ 20 min	Vc	128	−256	−227
	Body weight	Vc	140	−280	−248
	BNP	k10	143	−285	−251
FOCE ELS	MAP	k21	159	−318	−282

A reduction −2(LL) by 3.8 is significant by P < 0.05 and > 6.6 points by P < 0.01)

FOCE LB First-Order Conditional Estimation according to Lindstrom-Bates, FOCE ELS FOCE Extended Least Squares, LL Log likelihood, AIC Akaike Criterion