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. 2020 Apr 25;17:132. doi: 10.1186/s12974-020-01801-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Detection of Ca²⁺ signals and capacitance in BV-2 cells with and without an L-VGCC blockade. Fura-2 Ca²⁺ signals in untreated BV-2 cells used as the negative control (a). Amlodipine treated BV-2 cells used as the positive control (b). Amlodipine treated HEK293T cells used as assay specificity control (c). BV-2 cells treated with Zinc20267861 (d), Zinc18204217 (e), and Zinc33254827 (f). Electric cell-substrate impedance sensing (ECIS) evaluation of resistance (4 kHz) (g) and capacitance (16 kHz) (h) in BV-2 cells treated with Zinc20267861, Zinc18204217, Zinc33254827, and amlodipine 10 μM; 10% DMSO in PBS 5 μl/ml used as control over the 4-h period (n = 4)