Fig. 2.

Gene drive experiments. Arrows proceed from WT, ClvR^tko, or ClvR^dbe to some other ClvR-bearing state. The blunt end of the arrow indicates the starting state, and the pointed end the population state (transgene fixation) drive is meant to achieve. Color gradients schematically reflect progress from starting state to end state. Controls for each drive experiment are discussed in the text and in Figs. 3 and 4. Experiments demonstrating drive of ClvR^tko into a WT population (dashed outline) were published previously (25). See also SI Appendix, Fig. S6 for further characterization of the ClvR^tko experiment over more generations.