Fig. 4.

ClvRⁿ⁺¹+Rⁿ selfish elements drive into populations carrying ClvRⁿ. Shown are the drive outcomes for ClvR^dbe+R^tko driving into a population of w¹¹¹⁸ (red lines), ClvR^tko (green lines), and ClvR^dbe (gray lines, control) (A), and ClvR^tko+R^dbe driving into a population of w¹¹¹⁸ (red lines), ClvR^dbe (green lines), and ClvR^tko (gray lines, control) (B). There are four replicates for each drive experiment. Dashed black lines represent model estimated behavior for the spread of ClvRⁿ⁺¹ with no fitness cost into populations consisting primarily of ClvRⁿ population (see Methods for model details). Allele frequencies at generation 12 are presented in SI Appendix, Tables S11 and S12.