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. 2020 Apr 9;117(16):9064–9073. doi: 10.1073/pnas.1914505117

Fig. 4.

Fig. 4.

Effects of stable suppression of PHIP in U-251 transformants stably expressing anti-luc shRNA or anti-PHIP shRNA#1 in vivo. (A) Individual tumor volume measurements following s.c. injection of U-251 transformants. (B) Weight of s.c. U-251 tumors in the flanks of nude mice. (C) Tumor area following intracranial injection of U-251 transformants, with representative hematoxylin-eosin staining of intracranial tumors. (D) Microvessel density in intracranial tumors from U-251 transformants, with representative CD31 immunostaining in the intracranial tumors. (E) Quantification of VEGF levels by ELISA in U-251 transformants. All graphs represent mean ± SEM, *P < 0.05 versus control.