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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Biomaterials. 2020 Mar 20;245:119973. doi: 10.1016/j.biomaterials.2020.119973

Figure 4: Viscoelastic gels with 1:1 QK:RGD content and high stiffness promote the most indirect angiogenesis and direct osteogenesis.

Figure 4:

MSCs cultured in alginate gels of varying QK:RGD content (x-axes), stiffness (colored lines), and viscoelasticity (left versus right) exhibited differences in ability of conditioned medium to elicit hMVEC network formation, proliferation, and calcium deposition. Viscoelastic gels outperformed elastic gels in all outputs tested, with 17–20 kPa gels containing 1:1 or greater QK:RGD achieving the highest indirect network formation and direct proliferation/total calcium content (n=3). Representative images used to generate these data are shown in Supplementary Fig. S1b.