1. Order and percentage of appearance of the clinical symptoms during 255 malignant hyperthermia (MH) events.

Clinical symptom	Median of appearance number	Range of appearance number	Percentage of patients (%)
Clinical symptoms were listed in order of appearance. Appearance number was the numerical order in which a clinical symptom appeared such as the first clinical symptom that appeared during MH event would be marked 1. If the median of appearance number was same, the order of appearance depended on the percentage of MH patients.
Masseter spasm	1.00	1.00–4.00	26.7
Hypercarbia	2.00	1.00–8.00	92.2
Sinus tachycardia	2.00	1.00–7.00	72.9
Generalized muscle rigidity	2.00	1.00–6.00	40.8
Tachypnea	2.00	1.00–6.00	27.1
Cyanosis	2.00	1.00–7.00	9.4
Skin mottling	2.00	1.00–7.00	6.3
Rapidly increasing temperature	3.00	1.00–7.00	64.7
Elevated temperature	3.00	1.00–8.00	52.2
Sweating	4.00	1.00–8.00	17.6
Ventricular tachycardia	4.00	1.00–7.00	3.5
Cola-colored urine	5.00	2.00–9.00	13.7
Ventricular fibrillation	5.50	1.00–8.00	2.4
Excessive bleeding	6.00	4.00–8.00	2.7