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. 2020 Apr 21;15:2669–2683. doi: 10.2147/IJN.S249912

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© 2020 Li et al.

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ZnO NPs induced ROS accumulation and MMP loss in hiPSC-CMs. HiPSC-CMs were treated with ZnO NPs at 0, 25, 50, and 100 μM for 6 h. Immediately after treatment, cells were stained with CM-H2DCFDA (green), TMRM (red), and Hoechst 33342 (blue) respectively for ROS, MMP and nucleus. Representative fluorescent images of the cells by high-content analysis (A, Scale bar = 50 μm). Quantitative analysis of ROS and MMP fluorescence intensity (B and C). Data were presented as mean ± SE (n = 3). *Compared with control, P < 0.05.