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. 2020 Apr 21;12:2685–2695. doi: 10.2147/CMAR.S237181

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© 2020 Liu et al.

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The effects of lncRNA DLX6-AS1-mediated TRPC3 upregulation on cell proliferation and calcium homeostasis. (A) The effects of DLX6-AS1 specific siRNA on the expression levels of TRPC3 using Western blotting. **P<0.01. (B) The effects of Pyr3 and mitoTEMPO on the laryngeal cancer cell proliferation treated with siNC and siTRPC3, respectively. *P<0.05, **P<0.01. (C, D) The effects of Pyr3 and TRPC3 specific siRNA on cellular and mitochondrial ROS production, compared with DMSO or siNC, respectively. *P<0.05, ***P<0.001. (E, F) The effects of siTRPC3 on cellular calcium uptake, induced by thapsigargin, compared with siNC. The laryngeal cancer cells were preincubated with Fura-2, with F_x/F₀ indicated that the fluorescence values of certain dots versus the baseline of the measurements. **P<0.01. (G, H) The effects of TRPC3 inhibition on mitochondrial calcium uptake, induced by ATP in permeabilized cells. *P<0.05, **P<0.01, ***P<0.001.