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. Author manuscript; available in PMC: 2020 Jun 4.
Published in final edited form as: Mucosal Immunol. 2019 Dec 4;13(3):471–480. doi: 10.1038/s41385-019-0238-1

Figure 3. Antibiotics alter diversity of mucosal and stool bacterial communities.

Figure 3

(A) Species diversity, as measured by the Inverse Simpson Index, was altered by antibiotic treatment across all animals in the four antibiotic treatment groups. The colonic mucosa showed increased species diversity during (Day 3) and shortly after (Day 14) the antibiotic treatments. (B) Stool communities showed reduced diversity during (Days 0, 3, 7) and shortly after (Day 14) the antibiotic treatment. (C-D) Principal coordinates analysis confirmed that the antibiotics disrupted the community composition in the mucosa (C) and stool (D) during the antibiotic treatment. Green points indicate samples taken prior to the antibiotic treatment, red points indicate samples during the antibiotic treatment, and blue points indicate samples taken after cessation of the antibiotic treatment. Statistics were performed across all groups using a Wilcoxon signed-rank test and and corrected for multiple comparisons using a post-hoc Bonferroni correction.