Table 2.
Univariate and multivariate analysis of factors associated with late seizure
| No late seizure (n=2,430) |
Late seizure (n=77) |
Univariate OR (95% CI) |
p-value | Multivariate OR (95% CI) |
p-value | |
|---|---|---|---|---|---|---|
| Age, mean ± SD | 61.4 ± 14.4 | 57.0 ± 12.7 | 0.98 (0.96, 0.99) | 0.0086 | 0.98 (0.96, 0.99) | 0.0044 |
| Age in 5-year intervals | 0.90 (0.83, 0.97) | 0.0086 | 0.88 (0.81, 0.96) | 0.0044 | ||
| Race/Ethnicity | ||||||
| White non-Hispanic | 792 (32.6%) | 23 (29.9%) | Reference | |||
| Black non-Hispanic | 821 (33.8%) | 21 (27.3%) | 0.9 (0.5, 1.6) | 0.6782 | ||
| Hispanic | 817 (33.6%) | 33 (42.9%) | 1.4 (0.8, 2.4) | 0.2322 | ||
| Heavy alcohol use (> 5 drinks per day) | 220 (9.2%) | 10 (13.5%) | 1.5 (0.8, 3.0) | 0.2174 | ||
| Diabetes | 691 (28.4%) | 15 (19.5%) | 0.6 (0.3, 1.1) | 0.0881 | ||
| Treatment with AED during hospitalization | 975 (40.1%) | 53 (68.8%) | 3.3 (2.0, 5.4) | <0.0001 | 1.72 (1.00, 2.96) | 0.0488 |
| GCS at presentation, median (IQR) | 15 (13, 15) | 14 (9.5, 15) | 0.91 (0.86, 0.97) | 0.0016 | ||
| Volume of hematoma (cc), Gmean (95% CI) | 9.0 (8.5, 9.4) | 22.3 (17.5, 28.4) | 2.1 (1.7, 2.7) | <0.0001 | 1.45 (1.10, 1.91) | 0.0093 |
| Lobar location of ICH | 689 (29.0%) | 47 (61.8%) | 4.0 (2.5, 6.3) | <0.0001 | 2.67 (1.57, 4.54) | 0.0003 |
| Temporal lobe ICH | 240 (10.1%) | 12 (15.8%) | 1.7 (0.9, 3.1) | 0.1123 | ||
| Procedures | ||||||
| Intraventricular catheter/ ventriculostomy/ shunt placement | 425 (17.5%) | 21 (27.3%) | 1.8 (1.1, 3.0) | 0.0292 | ||
| Surgical evacuation of hematoma | 193 (7.9%) | 24 (31.2%) | 5.2 (3.2, 8.7) | <0.0001 | 2.50 (1.38, 4.55) | 0.0027 |
| Early seizure (seizure during hospitalization) | 173 (7.1%) | 13 (16.9%) | 2.7 (1.4, 4.9) | 0.0019 | ||
| Length of stay (days), median (IQR) | 8 (5, 17) | 13 (7, 28) | 1.01 (1.01, 1.02) | 0.0015 |