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. 2020 Apr 17;2020:2803747. doi: 10.1155/2020/2803747

Figure 1.

Figure 1

The effect of IL-1β pretreatment on ADMSC activation. (a) Expressions of α-SMA and COX-2 were upregulated at a dose-dependent manner when ADMSCs were treated with different concentrations of IL-1β (0, 20, 50, and 100 ng/ml) for 12 hr. (b) Expressions of α-SMA and COX-2 were upregulated at a time-dependent manner when ADMSCs were treated with 50 ng/ml IL-1β for different times (0, 6, 12, and 24 hrs). (c, d) Immunofluorescence staining indicated that IL-1β (50 ng/ml) treatment increased the expression of α-SMA and COX-2 in ADMSCs. (e–g) IL-1β treatment increased the secretion of PGE2, VEGF, and SDF-1 (∗P < 0.05 and ∗∗P < 0.01, Student's t test).