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. 2020 Apr 17;2020:2803747. doi: 10.1155/2020/2803747

Figure 2.

Figure 2

IL-1β treatment activated ADMSCs dependent on COX-2-PGE2 signaling. (a, b) COX-2 silencing impaired the effect of IL-1β on the upregulation of COX-2 and α-SMA expressions in ADMSCs. (c) COX-2 silencing impaired enhanced effect of IL-1β on PGE2 secretion in ADMSCs. (d, e) Silencing and inhibition of COX-2 expression impaired the promoted effect of IL-1β on SDF-1 and VEGF secretion in ADMSCs, whereas exogenous PGE2 rescued SDF-1 and VEGF secretion when IL-1β-pretreated ADMSCs were treated with COX-2 inhibitor, NS398 (∗∗P < 0.01, Bonferroni's multiple comparison).