Table 6.
Cluster membership in relation to cancer incidence in Iranian population in the Tehran Lipid and Glucose Study (1999–2014)
| Model 1a | Model 2b | |||||
|---|---|---|---|---|---|---|
| HR | (95% CI) | P value | HR | (95% CI) | P value | |
| Men | ||||||
| Cluster 5 | Reference | – | – | Reference | – | – |
| Cluster 1 | 5.38 | (1.89–15.33) | 0.002 | 2.56 | (0.89–7.39) | 0.080 |
| Cluster 2 | 5.17 | (1.73–15.49) | 0.003 | 2.65 | (0.87–8.03) | 0.083 |
| Cluster 3 | 7.75 | (2.73–22.01) | 0.003 | 3.56 | (1.23–10.28) | 0.018 |
| Cluster 4 | 4.76 | (1.66–13.61) | 0.001 | 2.46 | (0.85–7.11) | 0.096 |
| Cluster 6 | 2.60 | (0.78–8.63) | 0.118 | 3.05 | (0.91–10.14) | 0.068 |
| Cluster 7 | 2.58 | (0.87–7.65) | 0.085 | 2.23 | (0.75–6.62) | 0.146 |
| Women | ||||||
| Cluster 2 | Reference | – | – | Reference | – | – |
| Cluster 1 | 2.92 | (1.28–6.63) | 0.010 | 2.23 | (0.97–5.13) | 0.057 |
| Cluster 3 | 2.32 | (0.98–5.49) | 0.054 | 1.78 | (0.75–4.25) | 0.190 |
| Cluster 4 | 2.36 | (0.85–6.51) | 0.096 | 1.54 | (0.55–4.33) | 0.404 |
| Cluster 5 | 2.98 | (1.30–6.86) | 0.009 | 1.53 | (0.64–3.64) | 0.330 |
| Cluster 6 | 5.78 | (2.38–14.07) | <0.001 | 3.63 | (1.46–8.99) | 0.005 |
| Cluster 7 | 2.42 | (1.04–5.61) | 0.039 | 1.20 | (0.49–2.88) | 0.683 |
aModel was unadjusted
bModel was adjusted for age, smoking status, and educational and physical activity levels
In the Cox regression models, cluster 5 and cluster 2 in men and women, respectively, with the lowest incidence rates of cancer (Tables 2 and 3) were considered as reference groups
CI confidence interval, HR hazard ratio