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. 2020 Apr 25;17:17. doi: 10.1186/s12950-020-00247-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Nrdp1 promoted transcriptional activity of C/EBP-β. a Arg1 reporter activity in lysates was analyzed by Dual-Luciferase reporter assay system. Upregulation of Nrdp1 increased Arg1 reporter gene activation with a dose-dependent manner in the presence of IL-4 stimulation. b Arg1 reporter activity in lysates was detected, and luciferase activity was normalized to Renilla luciferase activity and was presented relative to basal luciferase activity. Knock down of C/EBP-β significantly attenuated Nrdp1-enhanced Arg1 gene activation. The differences were analyzed using ANOVA. *P < 0.05