Table 3.
Independent associations of six experimental factors with willingness to participate in clinical studies
| Willingness to participatea | |||
|---|---|---|---|
| Experimental factors assessed in two clinical vignettes | Odds ratio | 95% CI | p-value |
| Vignette 1 | |||
| Belief of greater effectiveness of the new drug (vs. clinical equipoise) | 0.77 | 0.62–0.95 | 0.013 |
| Random allocation of study drugs (vs. medical decision) | 0.99 | 0.81–1.22 | 0.949 |
| Public research funding (vs. research financed by a drug company) | 1.38 | 1.12–1.71 | 0.002 |
| Vignette 2 | |||
| Rare disease (vs. frequent, heart diseases) | 0.95 | 0.77–1.18 | 0.660 |
| Genetic analysis of specimens (vs. blood protein analyses) | 1.11 | 0.89–1.38 | 0.352 |
| Automatic reporting of test results to the participant (vs. reporting only upon request) | 1.15 | 0.92–1.43 | 0.220 |
Abbreviation: CI Confidence interval
aObtained by ordinal logistic regression model. Willingness to participate was rated on a 5-point Likert scale