Table 4.
Comparison of diagnostic performance of tests
| Test | Sensitivity % | Specificity % | PPV% | NPV% | Area under the curve (95% confidence interval) |
|---|---|---|---|---|---|
| RMI1 | 63 (17/27) | 93.8 (120/128) | 68 (17/25) | 92.3 (120/130) | .844 (0.740–0.947) |
| RMI2 | 66.7 (18/27) | 89.1 (114/128) | 56.3 (18/32) | 92.7 (114/123) | .851 (0.762–0.940) |
| RMI3 | 63 (17/27) | 90.6 (116/128) | 58.6 (17/29) | 92.1 (116/126) | .841 (0.749–0.932) |
| RMI4 | 66.7 (18/27) | 92.2 (118/128) | 64.3 (18/28) | 92.9 (118/127) | .841 (0.744–0.938) |
| ROMA | 59.3 (16/27) | 93 (119/128) | 64 (16/25) | 91.5 (119/130) | .886 (0.805–0.967) |
| HE4 | 37 (10/27) | 96.9 (124/128) | 71.4 (10/14) | 87.9 (124/141) | .798 (0.704–0.892) |
Data represented as percentages at 95% confidence interval PPV positive predictive value, NPV negative predictive value, RMI Risk of malignancy index, ROMA Risk Of Malignancy Algorithm, HE4 Human Epididymis Protein 4. Cut off for RMI1, RMI2, RMI3 was 200, for RMI4 was 450; for ROMA cut off for premenopausal was 11.4, for postmenopausal was 29.9; for HE4 cut off of 70 pmol/l was used