Table 6.

Comparison of performance of tests in premenopausal and postmenopausal groups

	Sensitivity	Specificity	Area Under the Curve (95% confidence interval)
Pre-menopausal
RMI 1	42.9%	91.5%	0.672 (0.432–0.912)
RMI 2	42.9%	87.7%	0.653 (0.416–0.890)
RMI 3	42.9%	87.7%	0.653 (0.416–0.890)
RMI 4	42.9%	90.6%	0.667 (0.428–0.907)
HE4	42.9%	98.1%	0.705 (0.459–0.950)
ROMA	42.9%	91.5%	0.672 (0.432–0.912)
Menopausal
RMI 1	72.2%	100%	0.861 (0.731–0.992)
RMI 2	77.8%	91.7%	0.847 (0.715–0.979)
RMI 3	72.2%	100%	0.861 (0.731–0.992)
RMI 4	77.8%	95.8%	0.868 (0.742–0.994)
HE4	77.8%	91.7%	0.653 (0.479–0.827)
ROMA	77.2%	100%	0.861 (0.731–0.992)

RMI Risk of malignancy index, ROMA Risk Of Malignancy Algorithm, HE4 Human Epididymis Protein 4