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Criteria for the determination of IBS-D severity by WAP, frequency of symptoms, BSFS and QoL. Cut-offs for severity levels were arbitrary and based on clinical experience; frequency was based on the number of days with IBS symptoms. BSFS Bristol Stool Form Scale; IBS irritable bowel syndrome; IBS-D diarrhoea-predominant irritable bowel syndrome; QoL quality of life; WAP worst abdominal pain
