Table 1.
Correlation of PENK expression with clinicopathological features of osteosarcoma
| Clinicopathological features | Number of cases (n) | PENK expression | P | |
|---|---|---|---|---|
| High (n) | Low (n) | |||
| Age | ||||
| < 25 years | 28 | 16 | 12 | 0.573 |
| ≥ 25 years | 12 | 8 | 4 | |
| Gender | ||||
| Male | 25 | 18 | 7 | 0.722 |
| Female | 15 | 10 | 5 | |
| Tumor size | ||||
| > 8 cm | 22 | 10 | 12 | 0.949 |
| ≤ 8 cm | 18 | 8 | 10 | |
| Anatomic location | ||||
| Tibia/femur | 30 | 20 | 10 | 0.702 |
| Elsewhere | 10 | 6 | 4 | |
| Serum level of lactate dehydrogenase | ||||
| Elevated | 25 | 15 | 10 | 0.191 |
| Normal | 15 | 12 | 3 | |
| Serum level of alkaline phosphatase | ||||
| Elevated | 31 | 16 | 15 | 0.162 |
| Normal | 9 | 7 | 2 | |
| Clinical stage | ||||
| IIA | 32 | 25 | 7 | 0.004 |
| IIB/III | 8 | 2 | 6 | |
| Pathology | ||||
| Osteoblastic | 15 | 8 | 7 | 0.966 |
| Chondroblastic | 10 | 5 | 5 | |
| Fibroblastic | 10 | 6 | 4 | |
| Telangiectatic | 5 | 3 | 2 | |
| Metastasis | ||||
| Absent | 30 | 15 | 15 | 0.583 |
| Present | 10 | 6 | 4 | |