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. 2020 Feb 15;31(4):244–260. doi: 10.1091/mbc.E19-05-0303

FIGURE 2:

FIGURE 2:

PI3K prevents Aβ42-induced microtubule dynamics deficits. (A–D) Still images of live recordings of EB1-GFP in ddA sensory neurons of third instar larvae. (E) Cartoon depicting the EB1 position in the plus-end of microtubules. (F–I) Quantification of GFP-tagged comet’s speed (F), length (G), duration (H), and density (I). Note the significant reduction of comet density by Aβ42 and its suppression by PI3K. Data represent mean ± SD. One-way ANOVA significances are indicated with **, p < 0.01 and *, p < 0.05 for comparisons with the control group. Scale bar is 50 µm.