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. 2020 Feb 15;31(4):244–260. doi: 10.1091/mbc.E19-05-0303

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© 2020 Arnés et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 9: — PI3K increases amyloid Aβ42 insoluble fraction in human cells. (A) Cartoon representing the experimental design in SHT-SY5Y cells differentiated and treated with Aβ42 oligomers (36 μg/ml) and PTD4-PI3KAc peptide (50 μg/ml) for 48 h. (B–E) Histograms representing total deposits (B), total area (C), deposits to area ratio (D), and deposit size distribution (E) in the cultures. (F) Representative confocal images of cell cultures showing Aβ (6E10; green) and DAPI (magenta) signals. Note the larger amyloid deposits in PI3K/Aβ42 with respect to Aβ42 (E, F). Data represent mean ± SD analyzed by Student’s t test. Scale bar is 10 µm. One-way ANOVA significance is indicated with *, p < 0.05.