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. Author manuscript; available in PMC: 2020 Apr 26.
Published in final edited form as: J Alzheimers Dis. 2019;72(4):1097–1117. doi: 10.3233/JAD-190849

Figure 2. Granisetron (GRS) increased tight junction proteins expression in isolated microvessels from mice brains compared to vehicle-treated mice (control, CTR).

Figure 2.

Representative western blots and densitometry analysis of the BBB tight junction proteins ZO-1, occludin, claudin-5 and JAM-1 in brain microvessels isolated from young (A), aged (B) wild type mice, and (C) TgSwDI mice. Statistical analysis was determined by Student’s t-test (n=5–7 mice). All values were normalized to CTR (1.0). Data are presented as box-and-whisker plots representing median and IQR, with minimum and maximum values. *P < 0.05, and **P < 0.01.