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. Author manuscript; available in PMC: 2020 Apr 26.
Published in final edited form as: J Alzheimers Dis. 2019;72(4):1097–1117. doi: 10.3233/JAD-190849

Figure 5. Granisetron (GRS) reduced Aβ brain load by reducing Aβ production and increasing Aβ clearance in TgSwDI mice brains.

Figure 5.

(A) Representative blots, and (B) densitometry analysis showed a significant increase in sAPPα and reduction in sAPPβ levels in granisetron treated group, with no significant effect on either BACE-1 enzyme or the nicastrin subunit of the γ-secretase enzyme in mice brains homogenates of TgSwDI mice. (C) Representative blots, and (D) densitometry analysis showed granisetron treatment significantly increased P-gp expression, a major Aβ clearance protein across the BBB, and reduced RAGE responsible for Aβ transport from blood to brain, but has no effect on LRP1. (E) Representative blots, and (F) densitometry analysis of major Aβ degrading enzymes IDE and neprilysin (NEP). Statistical analysis was determined by Student’s t-test (n=5 mice per group). Values were normalized to CTR (1.0). Data are presented as box-and-whisker plots representing median and IQR, with minimum and maximum values. ns=not significant, *P < 0.05, and **P < 0.01 versus control (CTR) group.