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. 2020 Apr 22;13:805–815. doi: 10.2147/JPR.S250391

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© 2020 Alghamdi.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Antinociceptive effect of eriocitrin in the postoperative nociception. (A) Expression of nociception after INCIS surgery. Each symbol represents mean paw withdrawal threshold in g±SEM. *P<0.05 as compared to the VEH administered group, Wilcoxon matched-pairs signed ranked test, n=6 mice per group. (B) Effect of ERCN on postoperative nociception expression. Each symbol represents mean paw withdrawal threshold in g±SEM. ^###P<0.05 as compared to the VEH administered group. *P<0.05, **P<0.01 as compared to the VEH administered incisional control group, two-way repeated measures ANOVA followed by Tukey’s post hoc test, n=6 mice per group.

Abbreviations: ERCN, eriocitrin; INCIS, incisional; Pre, pre-incisional surgery paw withdrawal threshold; BL, baseline paw withdrawal threshold before eriocitrin administration; VEH, vehicle.