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. 2020 Apr 22;13:805–815. doi: 10.2147/JPR.S250391

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© 2020 Alghamdi.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Effect of NALT and BICUC on ERCN antinociceptive effect in postoperative nociception. Each symbol represents the mean PWT in g±SEM. ^###P<0.05 as compared to the vehicle administered control group. ^$$P<0.01, ^$$$P<0.001 as compared to the VEH administered incisional control group, *P<0.05, **P<0.01 as compared to the ERCN alone administered incisional group, two-way repeated measures ANOVA followed by Tukey’s post hoc test, n=6 mice per group.

Abbreviation: BICUC, bicuculline; BL, baseline paw withdrawal threshold before administration of eriocitrin and antagonists; ERCN, eriocitrin; NALT, naltrexone; PWT, paw withdrawal threshold; VEH, vehivle.