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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: J Invest Dermatol. 2020 Apr 2;140(5):945–951. doi: 10.1016/j.jid.2019.12.011

Figure 2. The IgE-mediated versus Mrgprb2-mediated itch axis.

Figure 2.

Classical activation of mast cells by IgE results in the release of the monoamines such as histamine and serotonin. Mrgprb2 (murine)/MRGPRX2 (human) can be activated by various cationic substances, such as pro-adrenomedullin peptide 9–20 (PAMP 9–20), compound 48/80, drugs, neuropeptides (NPs), and host defense peptides (HDPs). Mrgbprb2-mediated activation of mast cells elicits distinct mechanisms of itch from classical IgE stimulation, in which tryptase is a major mediator while others such as histamine and serotonin are also included. Figure created with Biorender.