Table 3.

Comparison of baseline (Pre) vs. post treatment (Post), or following 12 weeks in healthy controls (HC), nodal graph theory metrics. Analysis was done with patients (PT) aggregated (All patients) and split by treatment cohort. P-values were determined with permutation tests, and are reported uncorrected (p-val) and corrected (q-val) via false discovery rate (FDR) control with n=12 (number of regions of interest). Positive mean effect values indicate that nodal metrics are increased at Post compared to Pre. Effect size is Cohen’s d. Abbreviations) CBT: cognitive behavioral therapy, SSRI: selective serotonin reuptake inhibitor.

cohort	region	metric	p-value	q-value	mean effect (%)	effect size
All patients					(Pre-Post)/Pre
	NA	NA	NA	NA	NA	NA
SSRI
	L Frontal Sup Orb	betweenness centrality	0.043	0.256	78.724	−0.845
	L Frontal Inf Orb	betweenness centrality	0.015	0.176	−45.546	0.970
CBT
	L Frontal Sup Orb	clustering coefficient	0.037	0.210	33.259	−0.622
	L Frontal Med Orb	clustering coefficient	0.022	0.210	17.730	−0.380
	R Frontal Inf Orb	local efficiency	0.050	0.165	2.863	0.084
	L Frontal Med Orb	local efficiency	0.030	0.165	20.642	−0.457
	L Amygdala	betweenness centrality	0.027	0.319	12.015	−0.163
HC
	NA	NA	NA	NA	NA	NA