Table 4.

Graph theory metric predictors of treatment response, determined with Spearman correlations between baseline graph theory metric and improvement in clinical assessment score (pretreatment minus post-treatment scores). Correlations were performed on aggregated patients (All PT), and with patients split by treatment cohort. P-values reported are uncorrected and from Spearman correlations. False discovery rate corrected p-values (q-value) are determined with n=12 (number of regions of interest). Negative rho indicates that greater nodal metrics correlate with lesser clinical improvement. Abbreviations) CBT: cognitive behavioral therapy, SSRI: selective serotonin reuptake inhibitor, HAMA: Hamilton anxiety rating scale, HAMD: Hamilton depression rating scale, DASS: depression, anxiety and stress scale.

cohort	region	metric	clinical assessment	p-value	q-value	rho
All PT
	NA	NA	NA	NA	NA	NA
SSRI
	R Frontal Sup Orb	betweenness centrality	HAMA	0.011	1.128	0.731
CBT
	R Frontal Inf Orb	strength	HAMA	0.006	0.071	−0.716
	L Frontal Med Orb	local efficiency	DASS	0.09	0.158	−0.576
	L Hippocampus	local efficiency	DASS	0.005	0.055	−0.73
	R Hippocampus	local efficiency	DASS	0.037	0.158	−0.581