Table 5.

Graph theory metric correlates of treatment response as determined with Spearman correlations between change in nodal metric (determined by post-treatment minus baseline values) and improvement in clinical assessment score (pretreatment minus post-treatment scores). Correlations were performed on metrics that were found to significantly change with treatment by permutation test (p<0.05). P-values from correlations are reported uncorrected (p) and false discovery rate corrected (q) with n=7 (total number of correlations performed). Abbreviations) CBT: cognitive behavioral therapy, SSRI: selective serotonin reuptake inhibitor, HAMA: Hamilton anxiety rating scale, HAMD: Hamilton depression rating scale, DASS: depression, anxiety and stress scale.

cohort	region	metric	clinical assessment	p-value	q-value	rho
All PT
	NA	NA	NA	NA	NA	NA
SSRI
	NA	NA	NA	NA	NA	NA
CBT
	L Frontal Sup Orb	clustering coefficient	DASS	0.008	0.084	0.694
	L Frontal Med Orb	clustering coefficient	DASS	0.042	0.084	0.57
	L Frontal Med Orb	local efficiency	DASS	0.019	0.075	0.639