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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Am J Transplant. 2019 Dec 9;20(5):1251–1261. doi: 10.1111/ajt.15701

Figure 1:

Figure 1:

BALT induction in tolerant lung allografts requires IL-22 and IL-23 expression. Histological appearance of Balb/c lung allografts (A) 7 and (B) 30 days after transplantation into B6 wildtype (WT) mice that received peri-operative costimulatory blockade, with arrow depicting BALT at 30 days. Relative RNA expression of (C) IL-22, (D) IL-23, (E) LTβ, and (F) IL-17 from whole lung lysates of naïve Balb/c lungs and transplanted lungs at days 7 and 30. Appearance of lung allografts 30 days after transplantation into (G) IL-22 deficient hosts or (H) wildtype recipients receiving IL-23 neutralization. Recipients were treated with peri-operative costimulatory blockade. Scale bars: 100μM. (I) Quantification of the number of lymphoid follicles per section 30 days after transplantation into various recipients. n≥4 for all conditions. * p<0.05; **p<0.01; ns=not significant.