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Expression of peripheral node addressin in lymphoid follicles is dependent on IL-22. Histological appearance and representative staining for PNAd (brown) in Balb/c lung allografts 30 days after transplantation into (A) wildtype (WT), (B) IL-22-deficient, (C) IL-23-neutralized, (D) AR (RORγt-cre Ahrfl/fl) mice, and (E) γδ T cell-deficient (TCRδ−/−) recipients. Recipient mice were treated with peri-operative costimulatory blockade. Scale bars: 50 μm.
