Table 1.
Baseline clinical characteristics by baseline type 2 diabetes status and study group.
| Baseline Type 2 Diabetes | Without Baseline Type 2 Diabetes | |||||
|---|---|---|---|---|---|---|
| Teen-LABS | LABS-2 | p-value | Teen-LABS | LABS-2 | p-value | |
| Age at Surgery, mean (SD) | 17.1 (1.36) | 40.3 (6.75) | <0.001 | 17.0 (1.56) | 36.4 (6.88) | <0.001 |
| Sex, % (n) | 0.67 | 0.72 | ||||
| Female | 80.0% (24) | 76.4% (107) | 77.9% (102) | 76.2% (189) | ||
| Male | 20.0% (6) | 23.6% (33) | 22.1% (29) | 23.8% (59) | ||
| White | 63.3% (19) | 76.4% (107) | 76.3% (100) | 81.9% (203) | ||
| Black | 30.0% (9) | 16.4% (23) | 14.5% (36) | 19.9% (26) | ||
| Other | 6.7% (2) | 7.1% (10) | 3.6% (9) | 3.8% (5) | ||
| Ethnicity, % (n) | 0.29 | 0.29 | ||||
| Non-Hispanic | 93.3% (28) | 97.1% (136) | 90.1% (118) | 93.2% (231) | ||
| Hispanic | 6.7% (2) | 2.9% (4) | 9.9% (13) | 6.9% (17) | ||
| Weight (kg), mean (SD) | 152.6 (30.64) | 147.9 (27.82) | 0.41 | 150.6 (30.35) | 143.9 (28.25) | 0.034 |
| BMI, mean (SD) | 54.4 (8.92) | 51.7 (8.02) | 0.11 | 53.5 (9.81) | 50.0 (7.40) | <0.001 |
| Lipid-lower medication use, % (n) | 10.0% (3) | 39.4% (54) | 0.002 | 4.6% (6) | 7.3% (18) | 0.31 |
| Anti-hypertension medication use, % (n) | 50.0% (15) | 70.1% (96) | 0.035 | 16.8% (22) | 34.3% (85) | <0.001 |
| RAAS Inhibitor use, % (n) | 36.7% (11) | 40.9% (56) | 0.67 | 8.4% (11) | 11.3% (28) | 0.38 |
| Elevated blood pressure, % (n) | 56.7% (17) | 80.3% (110) | 0.006 | 31.0% (40) | 52.4% (130) | <0.001 |
| Glucose (mg/dl), median (Q1,Q3) | 101 (90, 143) | 107.5 (93, 139) | 0.59 | 91 (84, 100) | 91 (85, 98) | 0.58 |
| Insulin (uU/mL), median (Q1,Q3) | 43.0 (26.8, 67.1) | 23.5 (15.8, 38.2) | 0.002 | 25.2 (15.1, 36.9) | 19.0 (13.3, 28.3) | 0.003 |
| HbA1c (%), mean (SD) | 6.6 (1.90) | 6.9 (1.51) | 0.33 | 5.2 (0.40) | 5.3 (0.40) | 0.11 |
| Hs-CRP (mg/dl), median (Q1,Q3) | 0.91 (0.35, 1.75) | 0.86 (0.54, 1.63) | 0.96 | 0.61 (0.32, 0.94) | 0.79 (0.43, 1.52) | 0.004 |
| LDL cholesterol (mg/dl), mean (SD) | 166 (31.69) | 179.4 (40.69) | 0.09 | 156.6 (28.46) | 182.3 (35.34) | <0.001 |
| HDL cholesterol (mg/dl), mean (SD) | 41.4 (11.64) | 40.8 (9.63) | 0.77 | 36.8 (8.34) | 43.1 (10.31) | <0.001 |
| LDL cholesterol (mg/dl), mean (SD) | 96.5 (27.45) | 102.9 (37.69) | 0.29 | 92.1 (25.1) | 111.8 (29.55) | <0.001 |
| Triglycerides (mg/dl), median (Q1,Q3) | 121 (98, 177) | 157 (110, 218) | 0.033 | 112.5 (81, 169) | 126 (90, 164) | 0.54 |
| Serum creatinine (mg/dl), mean (SD) | 0.65 (0.14) | 0.76 (0.27) | 0.002 | 0.67 (0.12) | 0.76 (0.62) | 0.038 |