Table 3.
Comparison of patients who had an MAP drop < 60 mmHg during intervention or not
| MAP < 60 mmHg | MAP ≥ 60 mmHg | p value | |
|---|---|---|---|
| n = 66 (57.4%) | n = 49 (42.6%) | ||
| Clinical data | |||
| Age (mean ± SD) | 66.3 ± 12.6 | 64.0 ± 13.5 | 0.36 |
| Male sex | 37 (56.1%) | 27 (55.1%) | 0.92 |
| Hypertension | 45 (68.2%) | 27 (55.1%) | 0.15 |
| Dyslipidaemia | 13 (19.7%) | 4 (8.2%) | 0.09 |
| Chronic heart diseaseb | 8 (12.1%) | 9 (18.4%) | 0.35 |
| Diabetes | 10 (15.2%) | 6 (12.2%) | 0.66 |
| Atrial fibrillation | 26 (39.4%) | 22 (44.9%) | 0.55 |
| Stroke of unknown symptom onset | 16 (24.2%) | 11 (22.4%) | 0.82 |
| NIHSS at admission (median, range) | 14 (4–25) | 15 (5–23) | 0.82 |
| Radiological findings | |||
| MCA/M1-occlusion | 49 (74.2%) | 38 (77.6%) | 0.68 |
| MCA/M2-occlusion | 6 (9.1%) | 7 (14.3%) | 0.38 |
| Intracranial ICA occlusion | 7 (10.6%) | 4 (8.2%) | 0.66 |
| CTA collateral scoring (TAN, median, range) | 2 (0–3) | 2 (0–3) | 0.26 |
| ASPECTS pre-intervention (median, range) | 9 (5–10) | 9 (3–10) | 0.45 |
| Intervention | |||
| Intravenous thrombolysis | 36 (54.5%) | 33 (67.3%) | 0.17 |
| Time to groin puncture (min, median, IQR) | 208, 85 | 196, 85 | 0.19 |
| Time to recanalization (min, median, IQR) | 265, 81 | 245, 91 | 0.32 |
| Anaesthesia duration (min, median, IQR) | 120, 58 | 106, 57 | 0.12 |
| Successful recanalization (TICI 2b–3) | 54 (81.8%) | 41 (83.7%) | 0.86 |
| Post-intervention | |||
| mRS 3 months post-stroke (median, range) | 4 (0–6) | 2 (0–6) | < 0.01 |
| Mortality at 3 months post-stroke | 10 (15.2%) | 4 (8.2%) | 0.26 |
| Periinterventional blood pressure | |||
| Preinterventional SAP (mean ± SD) | 150.4 ± 28.7 | 154.1 ± 26.1 | 0.49 |
| Preinterventional MAP (mean ± SD) | 105.5 ± 21.9 | 109.6 ± 16.2 | 0.30 |
| Preinterventional DAP (mean ± SD) | 80.4 ± 16.6 | 81.4 ± 13.2 | 0.73 |
| Minimal SAP (mean ± SD) | 77.9 ± 20.0 | 100.0 ± 12.5 | < 0.001 |
| Minimal MAP (mean ± SD) | 53.6 ± 10.4 | 68.9 ± 7.6 | < 0.001 |
| Minimal DAP (mean ± SD) | 42.1 ± 7.7 | 51.6 ± 7.8 | < 0.001 |
| Average SAP (mean ± SD) | 118.2 ± 17.0 | 130.6 ± 15.0 | < 0.001 |
| Average MAP (mean ± SD) | 76.3 ± 10.8 | 86.0 ± 15.8 | < 0.001 |
| Average DAP (mean ± SD) | 56.5 ± 8.6 | 65.0 ± 7.9 | < 0.001 |
| Lowest relative SAPa (mean ± SD) | 54.0% ± 16.4% | 67.7% ± 12.5% | < 0.001 |
| Lowest relative MAPa (mean ± SD) | 52.7% ± 14.4% | 65.8% ± 11.9% | < 0.001 |
| Lowest relative DAPa (mean ± SD) | 54.2% ± 13.3 | 65.1% ± 14.2 | < 0.001 |
ASPECTS Alberta stroke program early CT scores, CTA computed tomography angiography, DAP diastolic blood pressure, ICA internal carotid artery, IQR interquartile range, MAP mean arterial pressure, MCA middle cerebral artery, NIHSS National Institutes of Health Stroke Severity Scale, mRS modified Rankin Scale, SAP systolic arterial pressure, TICI thrombolysis in cerebral infarction
aRelative to preinterventional values
bCoronary artery disease, heart failure, cardiomyopathy or valve disease