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. 2020 Jan 22;35(6):1069–1079. doi: 10.1007/s00467-020-04472-z

Table 2.

Correlations of serum concentrations of different forms of 25-hydroxyvitamin D (25(OH)D), vitamin D-binding protein, albumin, weight, and chronic kidney disease-mineral and bone disease (CKD-MBD) measures by CKD stages

Total
25(OH)D
Bioavailable
25(OH)D
Free (measured)
25(OH)D
Free (calculated)
25(OH)D
VDBP
CKD 2–3 (n = 22)

Bioavailable

25(OH)D

0.74**

Free (measured)

25(OH)D

0.77** 0.98**

Free (calculated)

25(OH)D

0.87** 0.74** 0.73**
VDBP 0.13 − 0.03 0.11 − 0.29
Albumin − 0.54** − 0.13 − 0.20 − 0.45** − 0.15
Calcium (Cor) 0.31 0.10 0.16 0.14 0.51**
Phosphate 0.14 0.08 0 0.29 − 0.21
PTH − 0.09 0 − 0.01 0.03 − 0.25
Weight − 0.40 − 0.30 − 0.26 − 0.34 − 0.16
Dialysis (n = 18)

Bioavailable

25(OH)D

0.94**

Free (measured)

25(OH)D

0.92** 0.96**

Free (calculated)

25(OH)D

0.94** 0.95** 0.96**
VDBP − 0.35 − 0.41* − 0.47** − 0.53**
Albumin 0.15 0.25 0.12 0.24 − 0.24
Calcium (Cor) 0.08 0.02 0.11 0.11 0
Phosphate − 0.27 − 0.33 − 0.29 − 0.38 − 0.07
PTH − 0.13 − 0.10 0 − 0.08 − 0.30
Weight − 0.46* − 0.52** − 0.57** − 0.52** 0.09
Transplant (n = 21)

Bioavailable

25(OH)D

0.67**

Free (measured)

25(OH)D

0.64** 0.98**

Free (calculated)

25(OH)D

0.94** 0.79** 0.79**
VDBP − 0.14 − 0.59** − 0.65** − 0.42*
Albumin − 0.14 0.08 − 0.02 − 0.19 0.22
Calcium (Cor) − 0.19 0.02 0.08 − 0.08 − 0.07
Phosphate − 0.07 − 0.06 − 0.05 − 0.04 0.11
PTH − 0.71** − 0.73** − 0.72** − 0.74** 0.16
Weight − 0.04 − 0.23 − 0.30 − 0.16 0.36

Data represent spearman correlation. * p < 0.1; ** p < 0.05