Table 1.

Monoclonal antibodies

Drug	Etanercept (Enbrel)	Infliximab (Remicade)	Adalimumab (Humira)	Golimumab (Simponi, Simponi Aria)	Certolizumab (Cimzia)
Structure and mechanism of action	TNFR2 ectodomain fused to IgG1 binds TNF-α and TNF-β	Chimeric murine-human IgG1 that binds TNF-α	Fully humanized IgG1 that binds TNF-α	Fully humanized IgG1 that binds TNF-α	Humanized PEGylated Fab that binds TNF-α
Indications	RA, psoriatic arthritis, plaque psoriasis, ankylosing spondylitis, and juvenile idiopathic arthritis	RA, psoriatic arthritis, plaque psoriasis, ankylosing spondylitis, idiopathic pulmonary fibrosis, ulcerative colitis, and Crohn’s disease	RA, psoriatic arthritis, ankylosing spondylitis, spondyloarthritis, juvenile idiopathic arthritis, uveitis (intermediate, posterior, panuveitis), plaque psoriasis, hidradenitis suppurativa, ulcerative colitis, and Crohn’s disease	RA, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis	RA, psoriatic arthritis, ankylosing spondylitis, spondyloarthritis, and Crohn’s disease
Reported ocular side effects	Uveitis, scleritis, ON, and ocular myositis	Uveitis, ON, and endophthalmitis	Uveitis, ON, endophthalmitis, corneal infiltrates, retinal toxicity, and ophthalmoplegia	ON	ON