Table.
Clinical Characteristics of Three Children with Chronic Hepatitis C Virus (HCV) Genotype 1b Infection.
| Case 1 | Case 2 | Case 3 | ||||
|---|---|---|---|---|---|---|
| Age | 10y7m | 13y11m | 10y8m | |||
| Sex | Female | Female | Female | |||
| Body height (m) | 1.42 | 1.51 | 1.37 | |||
| Body weight (kg) | 48.9 | 38.0 | 30.9 | |||
| History of anti-HCV therapy | No | No | No | |||
| Leukocyte count (/mm3) | 7,480 | 5,260 | 8,720 | |||
| Hemoglobin (g/dL) | 13.9 | 13.1 | 13.8 | |||
| Platelet count (×104/µL) | 24.6 | 25.4 | 35.9 | |||
| Prothrombin activity (%) | 98 | 97 | 97 | |||
| Total bilirubin (mg/dL) | 0.7 | 1.1 | 0.5 | |||
| Aspartate aminotransferase (U/L) | 38 | 18 | 33 | |||
| Alanine aminotransferase (U/L) | 52 | 20 | 19 | |||
| Albumin (g/dL) | 4.2 | 4.3 | 4.7 | |||
| Alpha-fetoprotein (ng/mL) | 0.9 | 2.2 | 1.6 | |||
| FIB4 index | 0.22 | 0.21 | 0.22 | |||
| Fibroscan (kPa) | 5.3 | 3.7 | 3.0 | |||
| HCV genotype in children | 1b | 1b | 1b | |||
| HCV genotype in mothers | 1b | 1b | 1b | |||
| HCV RNA (log IU/mL) | 5.2 | 4.9 | 5.2 | |||
| NS3-D168 | Wild | Wild | Wild | |||
| NS5A-L31 | Wild | Mix (L>>I/V) | Wild | |||
| NS5A-Y93 | Wild | Wild | Wild | |||
| Regimens of DAAs | OBV+PTV/r | OBV+PTV/r | GLE+PIB | |||
| Doses of DAAs | OBV 25 mg | OBV 25 mg | GLE 300 mg | |||
| PTV 150 mg | PTV 150 mg | PIB 120 mg | ||||
| r 100 mg | r 100 mg |
OBV+PTV/r: ombitasvir+paritaprevir/ritonavir, GLE+PIB: glecaprevir+pibrentasvir