Figure 7.
Visually Evoked Spiking Activities Observed in Visual Cortex of rd10 Mice Having NOD-Enabled, MCO-II-Sensitized RGCs
(A) Setup for measuring visually evoked spiking activities in V1. (B) Top: spiking activities in visual cortex (V1) subsequent to visual stimulation of the MCO-II-expressing eye using no light and light with intensities of 1, 10, 79, and 220 cd⋅s/m2. Bottom: spiking activities in visual cortex (V1) at the same electrode location of the animal subsequent to visual stimulation of the PBS-injected eye using no light and light with intensities of 1, 10, 80, and 220 cd⋅s/m2. The visual stimulation light pulses were applied at 1 Hz (200 ms ON, 800 ms OFF) for 60 s. (C) Visual stimulation intensity-dependent cortical activities in rd10 mice. Mean + SD. ∗p < 0.05 between control and NOD eye. (D) Confocal fluorescence image of immunostained retina, showing the expression of MCO-II-mCherry in RGCs.