Table 3.
Combination Index (CI) of Curcumin, Chitosan Nanoparticles (CsNPs), and Curcumin Chitosan (CuCs) Nanocomposite on Huh7 Cells and Its Type of Interaction as Simulated with CompuSyn Software
| Fa | Sample | Curcumin Dose (µg/mL) | CsNPs Dose (µg/mL) | CI | Type of Interaction |
|---|---|---|---|---|---|
| 0.5 | Curcumin | 31.7768 | – | – | Synergism |
| CsNPs | – | 162.726 | – | ||
| CuCsNPs | 10.4478 | 2.61195 | 0.34484 | ||
| 0.75 | Curcumin | 48.2388 | – | – | Synergism |
| CsNPs | – | 193.592 | – | ||
| CsNPs-Cur | 27.4258 | 6.85644 | 0.60396 | ||
| 0.9 | Curcumin | 73.2291 | – | – | Slight antagonism |
| CSNPs | – | 230.312 | – | ||
| CuCsNPs | 71.9934 | 17.9983 | 1.06127 | ||
| 0.95 | Curcumin | 97.2713 | – | – | Antagonism |
| CsNPs | – | 259.190 | – | ||
| CuCsNPs | 138.792 | 34.6979 | 1.56072 | ||
| 0.97 | Curcumin | 119.046 | – | – | Severe antagonism |
| CsNPs | – | 281.917 | – | ||
| CuCsNPs | 221.410 | 55.33526 | 2.05621 |
Notes: CI < 1: Synergism, CI > 1: Antagonism, CI = 1: Additive.
Abbreviations: Fa, fraction effect; CI, Combination Index; DRI, Dose Reduction Index.