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. 2020 Apr 22;15:2751–2764. doi: 10.2147/IJN.S238536

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© 2020 Hu et al.

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(A) Endosomal escape of Cy7 labeled HP-ss-PEG-Tf in HepG2 cells following 2 or 6 h incubation observed by confocal microscopy (bar: 10 μm). (B) Influence of endocytic inhibitors on cellular uptake after pre-treating the HepG2 cells with specific endocytic inhibitors for 1 h followed by co-treatment with HP-ss-PEG-Tf/DOX for 1 h. The data are reported as the mean ± SD (n = 3), ***p < 0.001, N.S.: no significance.