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In vivo biodistribution of Cy7 labeled HP-ss-PEG-Tf and HP-ss-PEG conjugates. (A) In vivo fluorescence imaging of mice bearing HepG2 tumor after intravenous injection with Cy7-labeled HP-ss-PEG-Tf and HP-ss-PEG conjugates, respectively. The black dotted circle indicates the tumor region. (B) After 48 h, HP-ss-PEG-Tf and HP-ss-PEG conjugates treated mice were sacrificed, the major organs (heart, liver, spleen, kidney and lung) and tumors extracted, and measured by NIR.
