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. 2020 Apr 22;15:2751–2764. doi: 10.2147/IJN.S238536

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© 2020 Hu et al.

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In vivo antitumor efficacy of saline, P-PEG/DOX, HP-PEG/DOX, HP-ss-PEG/DOX, HP-ss-PEG-Tf/DOX and free DOX in HepG2 tumor bearing nude mice. (A) Relative tumor volume change; (B) Mice body weight change; (C) Tumor tissue images extracted from the mice at the end of treatment by various formulations; (D) Tumor growth inhibition of the different treatment groups. During the in vivo experiment, no mice died. The survival rate of tumorigenic mice models was 100%. Data were presented as mean ± SD (n = 6, *p< 0.05, ***p< 0.001, N.S.: no significance).