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Schematic diagram illustrating the mechanism by which CDKN2B-AS1 regulates atherosclerosis by forming RNA-DNA triplex to mediate CDKN2B. In atherosclerosis, CDKN2B-AS1 can inhibit macrophage reverse cholesterol transport and promote atherosclerotic plaque formation. This occurs by downregulating CDKN2B via RNA-DNA triplex with CDKN2B promoter to transfer CDKN2B-AS1-recruited EZH2 (for methylation of H3K27me3) to the CDKN2B promoter so that CTCF can bind to the CDKN2B promoter.
