Table 7.
The lipid accumulation in peritoneal macrophages of ApoE−/− mice with different treatments of CDKN2B-AS1 and CDKN2B (μg/mg cell protein).
| Group | TC | FC | CE | CE/TC (%) |
|---|---|---|---|---|
| sh-NC | 489.35 ± 18.22 | 187.46 ± 29.35 | 302.68 ± 28.15 | 61.95 |
| sh-CDKN2B-AS1 | 408.23 ± 32.16a | 146.38 ± 26.37a | 262.75 ± 33.68a | 64.66 |
| sh-CDKN2B | 607.35 ± 34.26a | 233.68 ± 21.33a | 374.29 ± 35.68a | 61.85 |
| sh-CDKN2B-AS1 + sh-CDKN2B | 503.46 ± 21.68b | 189.26 ± 31.28b | 314.21 ± 27.68b | 62.52 |
Note:
a
p < 0.05 vs. the sh-NC group.
b
p < 0.05 vs. the sh-CDKN2B group. All the experiments were repeated 3 times independently, and the data among multiple groups were analyzed by one-way analysis of variance; sh-NC, mice injected with pSIH1-H1-copGFP-sh-NC; sh-CDKN2B, mice injected with pSIH1-H1-copGFP-sh-CDKN2B; sh-CDKN2B-AS1, mice injected with pSIH1-H1-copGFP-sh-CDKN2B-AS1; sh-CDKN2B-AS1 + sh-CDKN2B, mice injected with pSIH1-H1-copGFP-sh-CDKN2B-AS1 and pSIH1-H1-copGFP-sh-CDKN2B; TC, total cholesterol; TG, triglyceride; LDL, low density lipoprotein.