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. 2020 Mar 18;36:100978. doi: 10.1016/j.molmet.2020.100978

Figure 8.

Figure 8

Proteome and metabolome alterations in specific metabolic pathways. Red indicates increased abundance, blue decreased abundance in GHR-KO vs. control liver samples. Significant differences are indicated by asterisks: ∗p < 0.05; ∗∗p < 0.01. A: Tricarboxylic acid (TCA) cycle. Abbreviations: LDH, lactate dehydrogenase; IDH, isocitrate dehydrogenase; FH, fumarate hydratase; MDH, malate dehydrogenase. B: Fatty acid beta-oxidation. Abbreviations: ACAD(V)L, acyl-CoA dehydrogenase (very)long chain; HSD17B10, 3-hydroxyacyl-CoA dehydrogenase type 2; CPT1A, carnitine palmitoyltransferase 1A. CPT1A activity was calculated as ratio of long-chain acylcarnitines to free carnitine. Differences in these parameters were tested for significance using student t-tests. C: Methionine cycle. Abbreviations: SAM, S-adenosyl-methionine; SAH, S-adenosyl-l-homocysteine; MAT, methionine adenosyltransferases; GNMT, glycine N-methyltransferase; CTH, cystathionine gamma-lyase; ATP, adenosine triphosphate; GSH, glutathione. °p < 0.07.